News
Foundation advisory committee CHEST editorial recommends avoiding augmentation therapy for Alpha-1 "carriers"
MIAMI—The Alpha-1 Foundation’s Medical and Scientific Advisory Committee (MASAC) suggests that physicians avoid prescribing augmentation therapy for so-called “carriers,” usually individuals with the MZ genotype.
The advice is contained in a commentary printed this week in CHEST, the journal of the American College of Chest Physicians.
The CHEST summary of the editorial reads:
“The use of IV augmentation therapy with plasma-derived alpha-1 antitrypsin (AAT) has become the standard of care for the treatment of pulmonary disease associated with the severe genetic deficiency of AAT.
“The Medical and Scientific Advisory Committee of the Alpha-1 Foundation has become aware that physicians are prescribing this expensive blood product for the treatment of individuals with a single abnormal AAT gene, primarily the PI*MZ genotype. We are aware of no evidence that such therapy is effective in this patient population. The most important therapeutic interventions in such patients remain smoking cessation and elimination of other risk factors for lung disease.
“This commentary discusses the treatment of AAT deficiency and the concerns regarding treatment of PI*MZ individuals. We conclude that clinicians should avoid prescribing augmentation therapy for this heterozygote population.”
